Twenty years after modern civilization has been destroyed. Joel, a hardened survivor, is hired to smuggle Ellie, a 14-year-old girl, out of an oppressive quarantine zone. What starts as a small job soon becomes a brutal, heartbreaking journey, as they both must traverse the U.S. and depend on each other for survival.

The story of several young people from around the world who represent the next stage in human evolution, possessing special powers, including the ability to teleport and communicate with each other telepathically. Together they work to defeat the forces of evil.