After years of being sheltered from the human world, the Turtle brothers set out to win the hearts of New Yorkers and be accepted as normal teenagers through heroic acts. Their new friend April O'Neil helps them take on a mysterious crime syndicate, but they soon get in over their heads when an army of mutants is unleashed upon them.

Shipwrecked in the South Pacific, a group of explorers encounter a menagerie of fearsome creatures — including the giant ape who rules the island: Kong.

Hope's commitment to the future is put to the test, jeopardising a potential reunion. Iris and Felix meet a new group. Startling revelations are made.